abstract：:Previous studies (including genome-wide association study (GWAS) and candidate gene studies) have revealed the important roles of genetic risk factors in schizophrenia, and RELN has been identified as a risk gene for this illness. We recently found that the low-density lipoprotein receptor-related protein 8 (LRP8), a ...

journal_title：Schizophrenia research

authors： Xiao X,Yu H,Li J,Wang L,Li L,Chang H,Zhang D,Yue W,Li M

更新日期：2020-01-01 00:00:00

abstract：:Around 1 in 5 children under 13 years old experience sub-clinical psychotic experiences (PEs) like hallucinations and delusions. While PEs in childhood are a significant risk factor for adult psychotic disorders, the majority of those experiencing childhood PEs do not develop a psychotic disorder. Individual differenc...

journal_title：Schizophrenia research

authors： Dooley N,O'Hanlon E,Healy C,Adair A,McCandless C,Coppinger D,Kelleher I,Clarke M,Leemans A,Frodl T,Cannon M

更新日期：2020-01-01 00:00:00

abstract：:Early intervention strategies in psychosis would significantly benefit from the identification of reliable prognostic biomarkers. Pattern classification methods have shown the feasibility of an early diagnosis of psychosis onset both in clinical and familial high-risk populations. Here we were interested in replicatin...

journal_title：Schizophrenia research

authors： Zarogianni E,Storkey AJ,Borgwardt S,Smieskova R,Studerus E,Riecher-Rössler A,Lawrie SM

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Recovery is the ultimate goal of psychosis treatment. Basic self-disturbances (BSDs) are non-psychotic phenomena associated with clinical outcome, present in prodromal, psychotic and residual phases of psychotic disorders. AIM:To investigate the relationship between BSDs and recovery seven years after first...

journal_title：Schizophrenia research

authors： Svendsen IH,Øie MG,Møller P,Nelson B,Haug E,Melle I

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The Discrimination and Stigma Scale (DISC-12) was specifically developed to measure experienced and anticipated discrimination reported by people with mental health problems. However, the length of the DISC-12 may represent a disadvantage especially in country settings with limited human capacity and infrast...

journal_title：Schizophrenia research

authors： Bakolis I,Thornicroft G,Vitoratou S,Rüsch N,Bonetto C,Lasalvia A,Evans-Lacko S

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:As efforts intensify to intervene early among those at risk for psychosis, examination of the relationship between presenting psychopathology and long-term functional outcome may guide treatment decision-making and offer a means to prevent or reduce chronic disability. METHODS:Data were collected through th...

journal_title：Schizophrenia research

authors： Burton CZ,Tso IF,Carrión RE,Niendam T,Adelsheim S,Auther AM,Cornblatt BA,Carter CS,Melton R,Sale TG,Taylor SF,McFarlane WR

更新日期：2019-10-01 00:00:00

abstract：:The immune hypothesis of schizophrenia has gained significant popularity in recent years in schizophrenia research. Evidence suggests that the peripheral immune system communicates with central nervous system and the effect propagates through microglial and lymphocyte crosstalk, especially during neuro-inflammation. A...

journal_title：Schizophrenia research

authors： Varun CN,Venkataswamy MM,Ravikumar R,Nagaraju R,Debnath M,Varambally S,Venkatasubramanian G,Ravi V

更新日期：2019-10-01 00:00:00

abstract：:A disturbance of "minimal self," - of the immediate sense of mine-ness inherent in experience-is hypothesized to be the core disturbance in schizophrenia. Research with the Examination of Anomalous Self Experience (EASE) has demonstrated the selective aggregation of anomalous self-experiences in the schizophrenia spec...

journal_title：Schizophrenia research

authors： Madeira L,Pienkos E,Filipe T,Melo M,Queiroz G,Eira J,Costa C,Figueira ML,Sass L

更新日期：2019-09-01 00:00:00

abstract：INTRODUCTION:There is mixed evidence about emotional processing abnormalities in schizophrenia and schizoaffective disorder, with self-reports and clinician ratings indicating significant differences between patients and controls, but studies of in-the-moment, self-reported emotional experience finding only small diffe...

journal_title：Schizophrenia research

authors： Castro MK,Bailey DH,Zinger JF,Martin EA

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:Psychosis is associated with increased subjective and altered endocrine and autonomic nervous system stress-reactivity. Psychosis patients often experience auditory verbal hallucinations, with negative voice content being particularly associated with distress. The present study developed a voice-simulation p...

journal_title：Schizophrenia research

authors： Baumeister D,Peters E,Pruessner J,Howes O,Chadwick P

更新日期：2019-08-01 00:00:00

abstract：:The current study investigated whether a previously reported beneficial effect of methadone maintenance therapy (MMT) on antiretroviral adherence is also present in relation to antipsychotic treatment for schizophrenia. Administrative data were linked over a 17-year period for 1996 people who were dually diagnosed wit...

journal_title：Schizophrenia research

authors： Rezansoff SN,Moniruzzaman A,Somers JM

更新日期：2019-08-01 00:00:00

abstract：:Previous studies have demonstrated that patients with schizophrenia and individuals with schizotypy experience decreased anticipatory pleasure. However, it is unclear whether this decrease is contributed by altered reward processing at the proximal or distal future. In order to investigate the preference for receiving...

journal_title：Schizophrenia research

authors： Cai XL,Weigl M,Liu BH,Cheung EFC,Ding JH,Chan RCK

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Anomalies in visual and auditory perception represent an important aspect of the symptomatic manifestation of schizophrenia (ScZ). However, there are currently no instruments available that allow the assessment of the full range of auditory and visual abnormalities using a self-report measure. METHODS:We de...

journal_title：Schizophrenia research

authors： Nikitova N,Keane BP,Demmin D,Silverstein SM,Uhlhaas PJ

更新日期：2019-07-01 00:00:00

abstract：:Executive dysfunction and language impairment are the most prominent neuropsychological models of formal thought disorder (FTD) in schizophrenia. However, available studies have provided contradictory findings regarding the accuracy of these models. Furthermore, specific neurocognitive underpinnings of positive FTD (P...

journal_title：Schizophrenia research

authors： Bora E,Yalincetin B,Akdede BB,Alptekin K

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Eye movement abnormalities have been identified in schizophrenia; however, their relevance to cognition is still unknown. In this study, we explored the general relationship between eye movements and cognitive function. METHODS:The three eye movement measures (scanpath length, horizontal position gain, and ...

journal_title：Schizophrenia research

authors： Morita K,Miura K,Fujimoto M,Yamamori H,Yasuda Y,Kudo N,Azechi H,Okada N,Koshiyama D,Ikeda M,Kasai K,Hashimoto R

更新日期：2019-07-01 00:00:00

abstract：:Outcomes for people with schizophrenia-spectrum disorders (SSDs) are generally poor, making it important to understand risk states and illness transition. The network approach, which conceptualizes psychopathology as a network of causally interacting symptoms, may hold promise in this regard. Here, we present a networ...

journal_title：Schizophrenia research

authors： Dodell-Feder D,Saxena A,Rutter L,Germine L

更新日期：2019-06-01 00:00:00

abstract：:Social dysfunction is a hallmark of schizophrenia. Social isolation may increase individuals' risk for psychotic symptom exacerbation and relapse. Monitoring and timely detection of shifts in social functioning are hampered by the limitations of traditional clinic-based assessment strategies. Ubiquitous mobile technol...

journal_title：Schizophrenia research

authors： Buck B,Scherer E,Brian R,Wang R,Wang W,Campbell A,Choudhury T,Hauser M,Kane JM,Ben-Zeev D

更新日期：2019-06-01 00:00:00

abstract：:The construct of Expressed Emotion (EE) is a reliable predictor of relapse in psychotic disorders globally. However, cultural differences in the level and manifestation of EE have been reported. This review was conducted in line with PRISMA guidelines to demonstrate the distribution of EE and its domains cross-cultura...

journal_title：Schizophrenia research

authors： O'Driscoll C,Sener SB,Angmark A,Shaikh M

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:There is evidence that schizophrenia is a neuro-immune disorder. Genes linked to intragenic LINE-1 methylation show a strong association with immune-associated disorders including psychosis. The aim of this study was to examine LINE-1 methylation patterns in paranoid schizophrenia and methamphetamine-induced...

journal_title：Schizophrenia research

authors： Kalayasiri R,Kraijak K,Mutirangura A,Maes M

更新日期：2019-06-01 00:00:00

abstract：:Deficits in N-methyl-d-aspartate-type (NMDAR) function contribute to cognitive deficits in schizophrenia, particularly dysfunction in neuroplasticity, defined as reduced learning during training on exercises that place implicit, increasing demands on early sensory (auditory and visual) information processing. Auditory...

journal_title：Schizophrenia research

authors： Kantrowitz JT

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:The 22q11.2 deletion syndrome (22q11DS) is one of the highest known risk factors for schizophrenia and recent findings have highlighted the clinical relevance of ultra-high risk (UHR) criteria in this population. However, studies in other at-risk populations have shown that the presence of negative symptoms ...

journal_title：Schizophrenia research

authors： Schneider M,Armando M,Schultze-Lutter F,Pontillo M,Vicari S,Debbané M,Eliez S

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:People with schizophrenia have an increased risk of premature mortality compared to the general population. We aimed to quantify which types of causes of death contributed to the excess mortality, and to examine whether there has been an increase in the excess mortality among persons with schizophrenia in th...

journal_title：Schizophrenia research

authors： Laursen TM,Plana-Ripoll O,Andersen PK,McGrath JJ,Toender A,Nordentoft M,Canudas-Romo V,Erlangsen A

更新日期：2019-04-01 00:00:00

abstract：:Previous studies suggest that schizophrenia-related visual perceptual abnormalities are primarily attributed to deficits of the dorsal rather than ventral visual pathway. In this study, we comparatively explored changes in dorsal and ventral networks in schizophrenia patients in both static and dynamic functional conn...

journal_title：Schizophrenia research

authors： Deng Y,Liu K,Cheng D,Zhang J,Chen H,Chen B,Li Y,Wang W,Kong Y,Wen G

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Neuropsychological impairment is common in schizophrenia and psychotic bipolar disorder. It has been hypothesized that the pathways leading to impairment differ between disorders. Cognitive impairment in schizophrenia is believed to result largely from atypical neurodevelopment, whereas bipolar disorder is i...

journal_title：Schizophrenia research

authors： Menkes MW,Armstrong K,Blackford JU,Heckers S,Woodward ND

更新日期：2019-04-01 00:00:00

abstract：:Planning and executing goal-directed behaviours are critical final steps in translating motivation into action. Amotivation is a key feature of schizophrenia, but its impact on goal-directed functioning has not been extensively studied in an objective and ecologically valid manner. To address this, we investigated goa...

journal_title：Schizophrenia research

authors： Siddiqui I,Saperia S,Fervaha G,Da Silva S,Jeffay E,Zakzanis KK,Agid O,Remington G,Foussias G

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:People with severe mental illness have greater risk of un-detected and inadequately treated medical disorders, adding up to the risk of premature death. This study investigated how chronic medical comorbidity evolved across the lifespan in schizophrenia and the associated impact on mortality. METHOD:A reg...

journal_title：Schizophrenia research

authors： Brink M,Green A,Bojesen AB,Lamberti JS,Conwell Y,Andersen K

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:While insight in schizophrenia improves with treatment, significant impairments often persist. The degree of persistence is not well characterised. AIMS:We assessed patient and clinician-rated changes in insight in acutely ill, minimally treated first-episode schizophrenia spectrum disorder patients over 24...

journal_title：Schizophrenia research

authors： Phahladira L,Asmal L,Kilian S,Chiliza B,Scheffler F,Luckhoff HK,du Plessis S,Emsley R

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:Childhood abuse and neglect are risk factors for psychotic symptoms. Early adversities may contribute to alterations in neuro/social cognition, which in turn is associated with psychosis. This study explored the possible mediating/moderating role of neuro/social cognition between childhood abuse and neglec...

journal_title：Schizophrenia research

authors： Mansueto G,Schruers K,Cosci F,van Os J,GROUP Investigators.

更新日期：2019-04-01 00:00:00

abstract：:Recent transcriptomic, proteomic and metabolomics studies have highlighted an abnormal cerebral glucose and energy metabolism as one of the potential pathophysiological mechanisms of schizophrenia. This raises the possibility that a metabolically-based intervention might have therapeutic value in the management of sch...

journal_title：Schizophrenia research

authors： Kraeuter AK,van den Buuse M,Sarnyai Z

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:Patients with schizophrenia have a high prevalence of metabolic disorders and cardiovascular mortality. It is possible that a vulnerability to metabolic abnormalities is associated with risk for psychosis, symptoms and functionality. In this study, we evaluate demographic information, cardiometabolic indices,...

journal_title：Schizophrenia research

authors： Cadenhead KS,Minichino A,Kelsven S,Addington J,Bearden C,Cannon TD,Cornblatt BA,Mathalon D,McGlashan TH,Perkins DO,Seidman LJ,Tsuang M,Walker EF,Woods SW,Yao J,North American Prodromal Longitudinal Studies (NAPLS) consortiu

更新日期：2019-02-01 00:00:00

abstract：:Omega-3 treatment studies for multi-episode schizophrenia or clinical high risk for conversion to psychosis states have had variable, and often negative, results. To examine adjunctive omega-3 treatment for recent onset psychosis, participants aged 15-40 years with recent onset schizophrenia-spectrum (n = 46) or bipol...

journal_title：Schizophrenia research

authors： Robinson DG,Gallego JA,John M,Hanna LA,Zhang JP,Birnbaum ML,Greenberg J,Naraine M,Peters BD,McNamara RK,Malhotra AK,Szeszko PR

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:A false sense of reality is a characteristic of schizophrenia spectrum disorders (SSD). Reality confusion may also emanate from posterior orbitofrontal cortex (OFC) lesions, as evident in confabulations that patients act upon and disorientation. This confusion can be measured by repeated runs of a continuous...

journal_title：Schizophrenia research

authors： Thézé R,Manuel AL,Pedrazzini E,Chantraine F,Patru MC,Nahum L,Guggisberg AG,Schnider A

更新日期：2019-02-01 00:00:00

abstract：:We investigated IL1B genetic variation previously associated with risk for transition to psychosis for its association with gene expression in human post-mortem dorsolateral prefrontal cortex (DLPFC) from 74 (37 schizophrenia, 37 control) individuals and brain structure in 92 (44 schizophrenia, 48 control) living indi...

journal_title：Schizophrenia research

authors： Mostaid MS,Dimitrakopoulos S,Wannan C,Cropley V,Weickert CS,Everall IP,Pantelis C,Bousman CA

更新日期：2019-02-01 00:00:00

abstract：:CACNA1C gene polymorphism rs2007044 has been reported to be associated with schizophrenia, but its underlying brain mechanism is not clear. First, we conducted an exploratory functional magnetic resonance imaging (fMRI) study using an N-BACK task and a Stroop task in 194 subjects (55 schizophrenia patients and 139 hea...

journal_title：Schizophrenia research

authors： Zhang Z,Wang Y,Zhang Q,Zhao W,Chen X,Zhai J,Chen M,Du B,Deng X,Ji F,Wang C,Xiang Y,Li D,Wu H,Dong Q,Chen C,Li J

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Deficient mirror neuron system (MNS)-activity is associated with social cognition deficits in schizophrenia. However, it is not known how socio-emotional contexts modulate the MNS-response. In a Transcranial Magnetic Stimulation (TMS)-experiment, we aimed to compare putative MNS-responses to action observati...

journal_title：Schizophrenia research

authors： Bagewadi VI,Mehta UM,Naik SS,Govindaraj R,Varambally S,Arumugham SS,Naveen Kumar C,Thirthalli J

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Cognitive Remediation (CR) is an evidence based treatment targeting cognitive and functional difficulties in people with psychosis. Despite the large number of effectiveness studies, only limited evidence exists for the active ingredients of this therapy. This study begins to fill this gap by exploring the r...

journal_title：Schizophrenia research

authors： Cella M,Wykes T

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Executive Functioning (EF) is an important factor for community functioning for people with severe mental illness. Cognitive remediation programs often improve EF, but do so by using multiple therapeutic techniques. Little is known regarding how individual treatment elements promote cognitive improvement. Os...

journal_title：Schizophrenia research

authors： Best MW,Gale D,Tran T,Haque MK,Bowie CR

更新日期：2019-01-01 00:00:00

abstract：:Treatments for cognitive and functional impairments associated with severe mental illnesses are urgently needed. We tested a 12-week, manualized, Compensatory Cognitive Training (CCT) intervention targeting prospective memory, attention, learning/memory, and executive functioning in the context of supported employment...

journal_title：Schizophrenia research

authors： Twamley EW,Thomas KR,Burton CZ,Vella L,Jeste DV,Heaton RK,McGurk SR

更新日期：2019-01-01 00:00:00

abstract：:Treatment resistant schizophrenia (TRS) is defined by poor or non-response to conventional antipsychotic agents. Functional capacity is defined as the baseline potential of a patient to function in the community, irrespective of actual achievements gained, and has never been studied in TRS. Here, we screened 182 patie...

journal_title：Schizophrenia research

authors： Iasevoli F,D'Ambrosio L,Notar Francesco D,Razzino E,Buonaguro EF,Giordano S,Patterson TL,de Bartolomeis A

更新日期：2018-12-01 00:00:00

abstract：:Classifications of psychotic disorders are moving towards utilizing dimensional symptom domains as the preferred mechanism for describing psychotic symptomatology. The ICD-11 has proposed six symptom domains (Positive symptoms, Negative symptoms, Depressive symptoms, Manic symptoms, Psychomotor symptoms, and Cognitive...

journal_title：Schizophrenia research

authors： Keeley JW,Gaebel W,First MB,Peterson DL,Rebello T,Sharan P,Reed GM

更新日期：2018-12-01 00:00:00